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Research Projects

The OVS lab overall goal is to study the impact of sweets during various period of development and diseases.

Image by Sharon McCutcheon

Nutrient-dependent O-GlcNAc cycling in development and disease

O-GlcNAcylation is one of the key components of diet-responsive signaling. This unique glucose rheostat is a ubiquitous and dynamic glycosylation of intracellular proteins with approximately 1000 modified proteins described to date. Two key enzymes drive O-GlcNAc cycling: The O-GlcNAc transferase (OGT) adds the modification and the O-GlcNAcase (OGA) removes it. Although many studies have focused on the decrease or complete absence of O-GlcNAc cycling by modulating the expression or activity of OGT, only a few studies have targeted hyper-O-GlcNAcylation by disturbing OGA. Because this post-translational modification is directly dependent on glucose input, depleting OGA creates an artificial and constant hyperglycemia-induced O-GlcNAcylation state. Using Oga and Ogt knockout (KO) cellular and mouse models, we can decipher the impact of high carbohydrate diet on embryonic development.

Non-Nutritive Sweeteners in pregnancy and lactation

Part of the lab is interested in understanding the impact of Non-Nutritive Sweeteners (NNS) consumption through pregnancy and lactation. Although, NNS have been found in mother’s milk and in placental blood circulation, no study has focused on the fundamental effect of those non-caloric sweeteners on the developing organism. Among the impacts described in adults are changes in intestinal hormonal secretion, glucose metabolism, gut dysbiosis and increase toxicity. Nevertheless, the fundamental mechanisms of those changes are far from understood. Therefore, we aim to understand the impact of NNS on detoxification and and proper placental protective role.


O-GlcNAcylation cycling in Pituitary Adenoma

Each year, there are approximately 10,000 new pituitary adenoma diagnoses is the US alone, with approximately 5,000 surgeries occurring annually for the resection of these tumors and annual surgical costs may reach $100 million. on the other hand, O-GlcNAcylation has been studied extensively in cancer development. indeed, increase of O-GlcNAcylation level is associated with cancer onset and many oncogene and tumor suppressor are regulated by O-GlcNAc modification. Therefore, we aim to study the impact of O-GlcNAc cycling in the development of pituitary adenoma.

The O-GlcNAc Database

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Image by Jan Antonin Kolar